Subjects with 2 ApoE4 genes are 12 times more likely to get AD than those with the normal gene (ApoE3)

So although scientists know that amyloid protein breakdown is important in the disease therapeutics targetting these proteins has been one long list of failures

This is a very interesting potential explanation – neurons produced from ApoE4 donor stem cells don’t function very well and breakdown to produce the characteristic amyloid

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