This article refers to the high placebo response rate (50%) in MDO specifically but equally appplies to all therapeutic areas >>>

>>>GET RECRUITMENT RIGHT
-True MDO patients
-True assessment by clinicians to select right subjects (keen to influence score on in/ex)
-Personnel lack of understanding of AIM = to test null hypothesis /estimate treatment effect

ALL skew recruitment distribution

>>>THEN GET THE CONDUCT RIGHT
-Need Training
-Meticulous monitoring
-Objectivity of measures

<<<MDO>>>